Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products.
نویسندگان
چکیده
A combination of an enantioselective conjugate addition/trapping sequence and a ruthenium(iii)-catalyzed domino cyclization provides a concise access to benzo[d]xanthenes found in several anti-influenza active sesquiterpene natural products.
منابع مشابه
Enantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerpenoid ineleganolide is disclosed. A palladium-catalyzed enantioselective allylic alkylation is employed to stereoselectively construct the requisite chiral tertiary ether and facilitate the synthesis of a 1,3-ciscyclopentenediol building block. Careful substrate design enabled the convergent asse...
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متن کاملEnantioselective, convergent synthesis of the ineleganolide core by a tandem annulation cascade† †Electronic supplementary information (ESI) available: Experimental procedures, 1H NMR, 13C NMR, and IR spectra, X-ray crystallographic data. CCDC 853379, 1061009–1061014 and 1061016. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc03347d Click here for additional data file. Click here for additional data file.
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerpenoid ineleganolide is disclosed. A palladium-catalyzed enantioselective allylic alkylation is employed to stereoselectively construct the requisite chiral tertiary ether and facilitate the synthesis of a 1,3-cis-cyclopentenediol building block. Careful substrate design enabled the convergent ass...
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An enantioselective and diastereoselective approach toward the synthesis of the tetracyclic scaffold of the furanobutenolide-derived polycyclic norditerpenoids is described. Focusing on synthetic efforts toward ineleganolide, the synthetic approach utilizes a palladium-catalyzed enantioselective allylic alkylation for the construction of the requisite chiral tertiary ether. A diastereoselective...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 8 8 شماره
صفحات -
تاریخ انتشار 2010